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Grant funders / South Dakota / Sioux Falls

Grant Funders in Sioux Falls, SD

Bespoke Grants indexes 49 grant-making foundations headquartered in Sioux Falls, South Dakota — together $309.6M in recent annual giving. Their giving most often supports health care, higher education, faith-based (christian) and arts & culture. Local funders are one of the best starting points for a Sioux Falls nonprofit, because many prioritize organizations in their own community.

49
Foundations in Sioux Falls
$309.6M
Combined annual giving
40
Listed below
SD
State

Foundations headquartered in Sioux Falls

Ranked by annual giving. Each links to a full profile — giving history, grant recipients, focus areas, and how to apply.

#FoundationAnnual givingLatest grant
1Esther and Harold Mertz Foundation$57.4M2024
2Sanford Group Return$49.6M2024
3Sanford Health Foundation$36.1M2024
4Sioux Falls Area Community$18.4M2024
5Sioux Falls Development$16.0M2024
6Avera Health$15.9M2023
7Edith Sanford Breast Cancer Foundation$15.5M2018
8Denny Sanford Foundation$10.3M2024
9Sfs Foundation$8.4M2025
10Sioux Empire United Way Inc$7.7M2024
11Aditi Foundation$6.6M2024
12The Evangelical Lutheran Good Samaritan$6.1M2024
13Sanford Health Foundation North$5.7M2024
14Butterfly House & Aquarium Inc$4.0M2022
15Margot and Tom Pritzker Foundation$3.5M2024
16Lifescape Foundation$3.2M2024
17David H Billion Foundation$3.0M2024
18Branches Foundation$2.9M2023
19Ch Robinson Worldwide Foundation$2.9M2024
20Mccrossan Foundation Inc$2.8M2025
21Via-bradley College of Engineering Found$2.7M2024
22Houston Family Foundation$2.6M2024
23Feeding South Dakota$2.3M2025
24Seeds of Change Foundation$2.0M2024
25The Luke Society Inc$1.5M2017
26South Dakota Association of Healthcare$1.5M2024
27Veterans of Foreign Wars of the Us$1.5M2023
28Children's Home Foundation$1.4M2025
29Raft Charitable Foundation$1.4M2023
30Milo Stip Charitable Remainder$1.4M2025
31Blythe Brenden-mann Foundation$1.4M2024
32Friends of South Dakota Public Broadcasting$1.3M2025
33Sanford Health Foundation West$1.1M2024
34Make-a-wish Foundation of South Dakota$985K2023
35Avera Mckennan$949K2023
36Comfort Family Foundation$913K2025
37First Lutheran Church Foundation$905K2024
38The Robert and Rita Elmen Foundation$787K2024
39Vasilius Family Foundation$786K2024
40The Evangelical Lutheran Good Samaritan$755K2020

Running a nonprofit in Sioux Falls?

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What Sioux Falls funders support

The causes most commonly funded by foundations based in Sioux Falls:

Health CareHigher EducationFaith-Based (Christian)Arts & CultureEducationFood & AgricultureMental HealthHousing & Homelessness

Beyond Sioux Falls

Local funders are a starting point, not the whole picture. Most Sioux Falls nonprofits are also eligible for statewide and national foundations — browse all grant funders in South Dakota, or let Bespoke Grants match your nonprofit to funders at every level for free.

About this page. Lists foundations whose IRS Form 990 filings give a Sioux Falls, SD address, drawn from Bespoke Grants' index of 225,000+ U.S. foundations and 13M+ grants. Foundations based elsewhere may also fund Sioux Falls nonprofits; the free funder match accounts for both.