| Fidelity Investments Charitable Gift Fund | Boston, MA | $7.32B |
| Bill & Melinda Gates Foundation Trust | Seattle, WA | $5.85B |
| Bill & Melinda Gates Foundation | Seattle, WA | $5.37B |
| Schwab Charitable Fund | San Francisco, CA | $3.30B |
| Novartis Patient Assistance Foundation | East Hanover, NJ | $3.26B |
| Feeding America | Chicago, IL | $3.20B |
| Vanguard Charitable Endowment Program | Southeastern, PA | $3.06B |
| Genentech Patient Foundation | South San Francisco, CA | $2.87B |
| Silicon Valley Community Foundation | Mountain View, CA | $2.64B |
| Johnson & Johnson Patient Assistance | New Brunswick, NJ | $2.49B |
| National Philanthropic Trust | Jenkintown, PA | $2.29B |
| Gavi Alliance | | $2.01B |
| Merck Patient Assistance Program Inc | Kenilworth, NJ | $1.58B |
| Goldman Sachs Philanthropy Fund | New York, NY | $1.57B |
| Gothic Corporation | Durham, NC | $1.50B |
| Direct Relief | Santa Barbara, CA | $1.46B |
| Bristol-myers Squibb Patient Assistance | Lawrenceville, NJ | $1.46B |
| Pfizer Patient Assistance Foundation Inc | New York, NY | $1.39B |
| Rural India Supporting Trust | Farmington Hills, MI | $1.38B |
| Mayo Clinic Group Return | Rochester, MN | $1.31B |
| Natl Christian Charitable Fdn Inc | Alpharetta, GA | $1.30B |
| Map International Inc | Brunswick, GA | $1.27B |
| NYU Langone Hospitals | New York, NY | $1.19B |
| Novo Nordisk Fonden | | $1.17B |
| Partners Healthcare System Inc & | Somerville, MA | $1.15B |
| Conference on Jewish Material Claims | New York, NY | $1.07B |
| Americares Foundation Inc | Stamford, CT | $1.02B |
| World Vision Inc | Federal Way, WA | $984.7M |
| American Online Giving Foundation Inc | Newark, DE | $979.0M |
| American Lebanese Syrian Associated | Memphis, TN | $974.7M |
| Bank of America Charitable Gift Fd | Boston, MA | $969.5M |
| Sanofi Cares North America | Bridgewater, NJ | $928.1M |
| Johns Hopkins University | Baltimore, MD | $905.3M |
| Mastercard Foundation | | $886.7M |
| Baptist Health South Florida Inc | Coral Gables, FL | $885.6M |
| President and Fellows of Harvard College | Cambridge, MA | $817.0M |
| Lilly Endowment Inc | Indianapolis, IN | $789.6M |
| The Trustees of Columbia University | New York, NY | $773.3M |
| New York University | New York, NY | $770.5M |
| The Ford Foundation | New York, NY | $760.8M |
| Cornell University | Ithaca, NY | $708.9M |
| The Big Ten Conference Inc | Rosemont, IL | $689.5M |
| Massachusetts Institute of Technology | Cambridge, MA | $681.0M |
| Network for Good | Washington, DC | $667.3M |
| Food for the Poor Inc | Coconut Creek, FL | $658.5M |
| Anc Healthcare Inc | Winter Park, FL | $653.5M |
| Mass General Brigham Incorporated | Somerville, MA | $652.4M |
| The Susan Thompson Buffett Foundation | Omaha, NE | $647.2M |
| University of Southern California | Los Angeles, CA | $642.7M |
| Trustees of Boston University | Boston, MA | $639.9M |
| Navigate Affordable Housing | Birmingham, AL | $639.4M |
| Morgan Stanley Global Impact Funding | Indianapolis, IN | $635.6M |
| Northwestern University | Evanston, IL | $608.0M |
| Tides Foundation | San Francisco, CA | $606.8M |
| Catholic Medical Mission Board Inc | New York, NY | $602.3M |
| Foundation to Promote Open Society | New York, NY | $593.3M |
| Compassion International Incorporated | Colorado Springs, CO | $588.6M |
| The Chicago Community Trust | Chicago, IL | $576.9M |
| University of Chicago | Chicago, IL | $572.2M |
| Boehringer Ingelheim Cares Foundation Inc | Ridgefield, CT | $560.4M |
| The Board of Trustees of the Leland Stanford | Redwood City, CA | $557.1M |
| Dechomai Asset Trust | Jacksonville, FL | $552.3M |
| University of Miami | Coral Gables, FL | $551.4M |
| Save the Children Federation Inc | Fairfield, CT | $551.3M |
| Yale University | New Haven, CT | $550.9M |
| Jewish Communal Fund | New York, NY | $536.1M |
| The Robert Wood Johnson Foundation | Princeton, NJ | $532.0M |
| Florida Clinical Practice Association | Gainesville, FL | $520.7M |
| Corporation for Public Broadcasting | Washington, DC | $519.1M |
| Mayo Clinic | Rochester, MN | $517.7M |
| American Endowment Foundation | Hudson, OH | $512.5M |
| Glaxosmithkline Patient Access | Philadelphia, PA | $505.5M |
| Trustees of the University of Pennsylvania | Philadelphia, PA | $503.8M |
| Dechomai Foundation Inc | Jacksonville, FL | $498.1M |
| The Bloomberg Family Foundation Inc | New York, NY | $497.1M |
| American National Red Cross & Its Constituent | Washington, DC | $496.4M |
| Walton Family Foundation Inc | Bentonville, AR | $496.2M |
| Illinois Network of Child Care Resource | Bloomington, IL | $492.7M |
| Emory University | Atlanta, GA | $486.6M |
| Pivotal Philanthropies Foundation | Redmond, WA | $484.7M |
| United States Fund for Unicef | New York, NY | $479.1M |
| Legal Services Corporation | Washington, DC | $474.1M |
| Service Credit Union | Portsmouth, NH | $473.6M |
| The William & Flora Hewlett Foundation | Menlo Park, CA | $471.3M |
| Future Forward USA Action | Washington, DC | $469.3M |
| Atlantic Coast Conference | Greensboro, NC | $464.0M |
| North Carolina Teachers and State | Raleigh, NC | $458.4M |
| International Olympic Committee | | $453.2M |
| Foundation for World Evangelism | | $448.0M |
| New Venture Fund | Washington, DC | $447.1M |
| Washington University | Saint Louis, MO | $443.3M |
| The Leona M and Harry B Helmsley | New York, NY | $440.9M |
| The George Washington University | Ashburn, VA | $429.3M |
| Bakerripley | Houston, TX | $428.7M |
| Wellspring Philanthropic Fund Inc | New York, NY | $428.2M |
| Foundation for the Carolinas | Charlotte, NC | $427.6M |
| Drexel University | Philadelphia, PA | $423.8M |
| The Andrew W Mellon Foundation | New York, NY | $420.9M |
| University of Oregon Foundation | Eugene, OR | $418.0M |
| Duke University | Durham, NC | $410.8M |
| The Trustees of Princeton University | Princeton, NJ | $407.8M |
| Northeastern University | Boston, MA | $407.0M |
| University of California San Francisco | San Francisco, CA | $405.3M |
| Pac-12 Conference | San Francisco, CA | $403.0M |
| University of Notre Dame Du Lac | Notre Dame, IN | $401.0M |
| Vanderbilt University | Nashville, TN | $397.3M |
| Medecins Sans Frontieres USA Inc | New York, NY | $392.6M |
| Renaissance Charitable Foundation Inc | Indianapolis, IN | $391.0M |
| Feed the Children Inc | Oklahoma City, OK | $387.5M |
| Grand Canyon University | Phoenix, AZ | $386.1M |
| The Big 12 Conference Inc | Irving, TX | $385.5M |
| Gothic Hsp Corporation | Durham, NC | $383.7M |
| Charles and Lynn Schusterman Family Foundation | Tulsa, OK | $365.3M |
| The David and Lucile Packard Foundation | Los Altos, CA | $363.5M |
| Bayer Us Patient Assistance Foundation | Whippany, NJ | $362.0M |
| The Jpb Foundation | New York, NY | $359.4M |
| Syracuse University | Syracuse, NY | $358.7M |
| Wk Kellogg Foundation Trust - No 5315 | Battle Creek, MI | $356.0M |
| Wheaton Franciscan Sisters | Wheaton, IL | $349.2M |
| Baylor University | Waco, TX | $341.9M |
| Brown University | Providence, RI | $340.0M |
| Dignity Health | San Francisco, CA | $336.7M |
| The Nebraska Medical Center | Omaha, NE | $335.8M |
| University of Pittsburgh | Pittsburgh, PA | $333.6M |
| Servant Foundation | Overland Park, KS | $332.9M |
| Center for Technology and Civic Life | Chicago, IL | $332.1M |
| UCLA Foundation | Los Angeles, CA | $327.9M |
| Sixteen Thirty Fund | Washington, DC | $324.9M |
| National Fish and Wildlife Foundation | Washington, DC | $323.2M |
| Charities Aid Foundation America | Alexandria, VA | $322.4M |
| The Rotary Foundation of Rotary | Evanston, IL | $313.5M |
| Kaiser Foundation Health Plan Inc | Oakland, CA | $312.6M |
| John D and Catherine T Macarthur Foundation (consolidated) | Chicago, IL | $311.5M |
| The Bank of America Charitable | Charlotte, NC | $309.1M |
| Sequoia Climate Foundation | Irvine, CA | $305.4M |
| Convoy of Hope | Springfield, MO | $305.2M |
| Liberty University Inc | Lynchburg, VA | $303.6M |
| Blue Meridian Partners Inc | New York, NY | $302.3M |
| Paypal Charitable Giving Fund | Washington, DC | $302.1M |
| Wells Fargo Foundation | Minneapolis, MN | $299.3M |
| St John's University New York | Jamaica, NY | $296.8M |
| Wk Kellogg Foundation | Battle Creek, MI | $295.1M |
| Stand Together C4 Fund | Arlington, VA | $294.1M |
| The Simons Foundation Inc | New York, NY | $294.0M |
| California Community Foundation | Los Angeles, CA | $291.0M |
| Greater Kansas City Community Foundation | Kansas City, MO | $289.2M |
| Hackensack Meridian Health Inc-subordinates | Edison, NJ | $286.7M |
| The University of British Columbia | | $284.5M |
| Los Angeles Regional Food Bank | Los Angeles, CA | $283.2M |
| Volkswagenstiftung | Salt Lake City, UT | $281.4M |
| U of O Foundation Supporting | Eugene, OR | $280.2M |
| Nsn Foundation Inc | Roseland, NJ | $279.0M |
| Greater Horizons | Kansas City, MO | $276.9M |
| Friday Foundation | Medina, WA | $273.9M |
| International Rescue Committee Inc | New York, NY | $273.7M |
| Gordon E and Betty I Moore Foundation | Palo Alto, CA | $272.1M |
| National Collegiate Athletic Association | Indianapolis, IN | $269.8M |
| Depaul University | Chicago, IL | $268.5M |
| Governing Council of the University of Toronto | | $268.0M |
| The Lord Foundation of North Carolina | Durham, NC | $266.5M |
| The Blackbaud Giving Fund | Charleston, SC | $266.4M |
| The New York Community Trust | New York, NY | $264.0M |
| Matthew 25 Ministries Inc | Cincinnati, OH | $263.3M |
| University of Georgia Research Foundation Inc | Athens, GA | $260.6M |
| Alfred I Dupont Charitable Trust | Jacksonville, FL | $260.2M |
| Fordham University | Bronx, NY | $258.0M |
| Georgetown University | Washington, DC | $255.3M |
| Jobsohio Beverage System | Columbus, OH | $255.0M |
| The Administrators of the Tulane Educational Fund | New Orleans, LA | $254.8M |
| The American Jewish Joint Distribution | New York, NY | $253.8M |
| Family Health International | Durham, NC | $253.1M |
| Chronic Disease Fund Inc | Frisco, TX | $253.0M |
| Loyola University of Chicago | Chicago, IL | $252.9M |
| Scott & White Healthcare | Dallas, TX | $251.1M |
| Rochester Institute of Technology | Rochester, NY | $248.7M |
| Florida Essential Healthcare | Austin, TX | $248.0M |
| University of California Berkeley Foundation | Berkeley, CA | $247.7M |
| Samaritan's Purse | Boone, NC | $247.7M |
| The Ayco Charitable Foundation | Cohoes, NY | $247.0M |
| Sergey Brin Family Foundation | San Francisco, CA | $245.8M |
| University of Wisconsin Foundation | Madison, WI | $243.9M |
| Rockefeller Philanthropy Advisors Inc | New York, NY | $242.2M |
| Flower Hospital | Toledo, OH | $236.7M |
| Jobsohio | Columbus, OH | $233.1M |
| Local Initiatives Support Corporation | New York, NY | $232.8M |
| Rensselaer Polytechnic Institute | Troy, NY | $229.7M |
| Trustees of Boston College | Chestnut Hill, MA | $228.3M |
| The San Francisco Foundation | San Francisco, CA | $228.0M |
| Kaiser Foundation Hospitals | Oakland, CA | $226.8M |
| Osf Genprof Liability | Pittsburgh, PA | $224.9M |
| Mgb Pooled Holdings LLC | Somerville, MA | $224.1M |
| Southern Methodist University | Dallas, TX | $221.7M |
| The Jewish Federations of North America Inc | New York, NY | $219.3M |
| Carnegie Mellon University | Pittsburgh, PA | $219.0M |
| Jpmorgan Chase Foundation | New York, NY | $217.6M |
| University of Illinois Foundation | Urbana, IL | $215.8M |
| University of Dayton | Dayton, OH | $215.5M |
| Temple University - of the Commonwealth System of Higher Education | Philadelphia, PA | $213.7M |
| Boston Foundation Inc | Boston, MA | $213.5M |
| Chan Zuckerberg Initiative Foundation | Palo Alto, CA | $213.3M |
| University of Denver | Denver, CO | $213.2M |
| United Nations Foundation Inc | Washington, DC | $212.6M |
| Laura and John Arnold Foundation | Houston, TX | $212.5M |
| The Sherwood Foundation | Omaha, NE | $212.4M |
| Givedirectly Inc | New York, NY | $211.7M |
| Natasha Foundation Inc | | $210.5M |
| University Medical Service | Tampa, FL | $208.7M |
| Novo Foundation | Brooklyn, NY | $208.4M |
| Conrad N Hilton Foundation | Agoura Hills, CA | $207.6M |
| Marble Freedom Trust | Centerville, UT | $206.8M |
| Genzyme Charitable Foundation Inc | Bridgewater, NJ | $204.4M |
| Combined Jewish Philanthropies of Greater Boston Inc | Boston, MA | $203.4M |
| Greater Chicago Food Depository | Chicago, IL | $203.1M |
| Central Florida Behavioral | Tampa, FL | $202.2M |
| University of Minnesota Foundation | Minneapolis, MN | $202.0M |
| Fund for Policy Reform Inc | New York, NY | $201.1M |
| University of Delaware | Newark, DE | $200.9M |
| Texas Christian University | Fort Worth, TX | $199.8M |
| The Columbus Foundation | Columbus, OH | $199.5M |
| The Oregon Community Foundation | Portland, OR | $199.2M |
| Fund for Policy Reform | Wilmington, DE | $196.0M |
| The Marcus Foundation Inc | Atlanta, GA | $194.5M |
| Educational Credit Management Corporation | Minneapolis, MN | $194.2M |
| Trustees of Dartmouth College | Hanover, NH | $192.6M |
| The Chancellor Masters and Scholars | | $191.4M |
| Calhfa Homeowner Relief Corporation | Sacremento, CA | $191.4M |
| The Pew Memorial Trust | Philadelphia, PA | $190.4M |
| The Sunderland Foundation | Overland Park, KS | $188.5M |
| Population Services International | Washington, DC | $187.5M |
| Good Ventures | Mountain View, CA | $187.3M |
| Cystic Fibrosis Foundation | Bethesda, MD | $187.2M |
| Marquette University | Milwaukee, WI | $186.8M |
| Great River Foundation Inc | West Burlington, IA | $186.0M |
| The Community Foundation for Greater | Atlanta, GA | $184.9M |
| Donors Trust Inc | Alexandria, VA | $182.5M |
| University of Colorado Foundation | Denver, CO | $182.3M |
| Bright Future Fund | Washington, DC | $182.1M |
| Impactassetsinc | Bethesda, MD | $181.3M |
| Cooperative for Assistance and Relief | Atlanta, GA | $180.4M |
| Upmc Group | Pittsburgh, PA | $180.3M |
| Feeding America Tampa Bay Inc | Tampa, FL | $179.5M |
| The Goldman Sachs Charitable Gift Fund | New York, NY | $178.9M |
| International Committee of the Red Cross | | $178.0M |
| Seattle Foundation | Seattle, WA | $177.7M |
| Wisconsin Alumni Research Foundation | Madison, WI | $175.9M |
| University of Washington Foundation | Seattle, WA | $175.9M |
| The Rockefeller Foundation | New York, NY | $175.1M |
| Gerson Bakar Foundation | San Francisco, CA | $174.6M |
| The University of Queensland | | $174.0M |
| American University | Washington, DC | $174.0M |
| Ncf Charitable Trust | Clearwater, FL | $173.5M |
| Trustees of Tufts College | Somerville, MA | $172.3M |
| The Us Charitable Gift Trust | Boston, MA | $172.1M |
| The Duke Endowment | Charlotte, NC | $171.7M |
| Windgate Charitable Foundation Inc | Little Rock, AR | $171.5M |
| Teva Cares Foundation | Parsippany, NJ | $171.5M |
| Robin Hood Foundation | New York, NY | $171.3M |
| Indiana University Foundation Inc | Bloomington, IN | $170.3M |
| University of Florida Jacksonville | Jacksonville, FL | $170.3M |
| The Leukemia & Lymphoma Societyinc | Rye Brook, NY | $169.6M |
| University of Nebraska Foundation | Lincoln, NE | $169.6M |
| The Children's Hospital of Philadelphia | Philadelphia, PA | $169.4M |
| Hofstra University | Hempstead, NY | $169.2M |
| United Way Worldwide | Alexandria, VA | $169.0M |
| Institute of International Education | New York, NY | $168.7M |
| Otsuka Patient Assistance Foundation Inc | Princeton, NJ | $168.4M |
| Community Foundation of Greater | Memphis, TN | $168.3M |
| Children's Health System of Texas | Dallas, TX | $166.6M |
| Planned Parenthood Federation of America Inc | New York, NY | $166.3M |
| Global Empowerment Mission Inc | Doral, FL | $165.9M |
| Chapman University | Orange, CA | $165.7M |
| Carnegie Corporation of New York | New York, NY | $165.2M |
| St Mary's Food Bank Alliance | Phoenix, AZ | $163.5M |
| United Jewish Appeal-federation of | New York, NY | $163.4M |
| Ani Rare Disease Patient Assistance Program | Baudette, MN | $161.8M |
| Greater Houston Community Foundation | Houston, TX | $160.5M |
| Means Database Inc | Washington, DC | $160.3M |
| The Kansas University Endowment Association | Lawrence, KS | $160.0M |
| Villanova University | Villanova, PA | $159.7M |
| The California Endowment | Los Angeles, CA | $159.5M |
| City of Hope | Duarte, CA | $159.1M |
| Seton Hall University | South Orange, NJ | $158.7M |
| The Rare Disease Charitable Foundation | Lexington, MA | $157.2M |
| Quinnipiac University | Hamden, CT | $156.8M |
| The University of Florida | Gainesville, FL | $156.7M |
| Ncrc Community Development Fund Inc | Washington, DC | $156.7M |
| Wal-mart Foundation | Bentonville, AR | $156.6M |
| UC San Diego Foundation | La Jolla, CA | $156.6M |
| Pef Israel Endowment Funds Inc | New York, NY | $155.9M |
| Robert W Woodruff Foundation Inc | Atlanta, GA | $155.5M |
| The Kresge Foundation | Troy, MI | $153.5M |
| Jewish Federation of Metropolitan | Chicago, IL | $153.4M |
| University of St Thomas | St Paul, MN | $153.3M |
| Second Harvest Inland Northwest | Spokane, WA | $151.6M |
| Dr Miriam & Sheldon G Adelson | Las Vegas, NV | $151.3M |
| Cal Poly Pomona Foundation Inc | Pomona, CA | $151.2M |
| The Cleveland Clinic Foundation | Independence, OH | $150.8M |
| Advocate North Side Health Network | Downers Grove, IL | $150.0M |
| New York-presbyterian Fund Inc | New York, NY | $150.0M |
| Good Ventures Foundation | Palo Alto, CA | $150.0M |